Strutural Determination of Certain Novel ER Complexes

Abstract

Tamoxifen is effective for the prevention and treatment of estrogen-dependent breast cancers, but is associated with an increased incidence of endometrial tumors. We completed the first aim of this psoposal to solve the crystal structure of the estrogen receptor alpha ligand-binding domain (ERalphaLBD) bound to the structurally similar compound GW5638, which has therapeutic potential and does not stimulate the uterus.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2006
Accession Number
ADA466712

Entities

People

  • Geoffrey L Greene
  • Ya-ling Wu

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Albumins
  • Alkenes
  • Androgen Receptors
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Chemistry
  • Crystal Lattices
  • Crystal Structure
  • Crystals
  • Electron Density
  • Neoplasms
  • North Carolina
  • Proteins
  • Recognition
  • United States
  • Uterine Cancers

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Nanofabrication and Microfabrication.