Decipher the Transcriptional Program in Prostate Cancer Cells

Abstract

A systematic computational approach is proposed to characterize the transcriptional factor binding sites and related molecular pathways involved in prostate caner, based on the available expression data generated from systems approaches on prostate cancer cells as well as comparative genomics data from the human and mouse genome sequencing projects. Androgen Response pathways in LNCaP and CL-1 cells are analyzed and re-constructed from MPSS and ICAT experiment datasets, the TRANSFAC data base, the Mogul scanner, and the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway data base.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA466803

Entities

People

  • Xiaowei Yan

Organizations

  • Institute for Systems Biology

Tags

DTIC Thesaurus Topics

  • Androgens
  • Databases
  • Genomics
  • Interdisciplinary Science
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Systems Analysis
  • Systems Approach
  • Systems Science

Fields of Study

  • Biology

Readers

  • Database Systems and Applications
  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.