Integration of Soluble and Adhesive Gradient Signals in Directed Cell Migration

Abstract

Our research has led to a comprehensive model of fibroblasts' responsiveness to PDGF gradient stimulation at the level of PI 3-kinase signaling, and we have analyzed the implications of this mechanism for dermal wound invasion. In this research, we have utilized and in some cases developed advanced tools for live-cell microscopy and quantitative analysis including mathematical modeling. Thus, our research has contributed to the fundamental understanding of directed fibroblast migration, a critical process in wound healing.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA467054

Entities

People

  • Jason M. Haugh

Organizations

  • North Carolina State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Adhesives
  • Biology
  • Cell Biology
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Engineering
  • Engineering
  • Engineers
  • Environmental Health
  • Geometry
  • Growth Factors
  • Mathematical Models
  • North Carolina
  • Polarity
  • Wound Healing

Readers

  • Molecular Biology and Genetics
  • Reinforced Composite Materials
  • Research Science/Academic Research