Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2

Abstract

The goal of this project is to determine if group A p21-activated kinases (Paks) are important elements in signaling in neurofibromatosis type II (NF2). Our hypothesis is that activation of the NF2 gene disrupts a signaling pathway emanating from the small GTPase Rac and its effector, p21-activated kinase (Pak). We propose that stimulation of the Rac/Pak signaling axis in cells lacking Merlin leads to changes in transcriptional activity and cytoskeletal dynamics, ultimately resulting in enhanced cell proliferation and motility, which are hallmarks of tumorigenesis.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA467572

Entities

People

  • Jonathan Chernoff

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Continents
  • Diseases And Disorders
  • Dynamics
  • Geographic Regions
  • Maryland
  • Neoplasms
  • Neurofibromatosis
  • North America
  • Pennsylvania
  • Scientific Research
  • United States

Fields of Study

  • Biology

Readers

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  • Neurological Diseases/Conditions/Disorders