Neurofibromatosis and the Painful Neuroma

Abstract

Pain is a common and distressing symptom that impacts the quality of life of many patients with neurofibromatosis. The pain is often due to the formation of a neuroma. To understand better how neuromas cause pain and what treatments may be provided, we have attempted to develop an animal model of a painful neuroma. We have completed the first of the three specific aims in this research project. The tibial neuroma transposition (TNT) model has been confirmed as a model of neuropathic pain. The TNT model has been established as reliable and valid. In the TNT model, the neuroma test-site mechanosensitivity is dependent on neural input from the tibial neuroma. In the TNT model, hindpaw mechanical hyperalgesia is independent of input from the tibial neuroma. We will now move on with work related to developing methods to prevent painful neuroma formation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA467583

Entities

People

  • Allan J. Belzberg

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Biomedical Research
  • Connective Tissue
  • Experimental Design
  • Frequency
  • Health Services
  • Nerves
  • Neurofibromatosis
  • Neuroma
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Skin
  • Spine
  • Statistical Analysis
  • Surgery
  • Test Methods
  • Tissues

Fields of Study

  • Medicine

Readers

  • Computational Modeling and Simulation
  • Neurotrauma and Rehabilitation Medicine.