Mechanism of Tumor Metastasis Suppression by the KA11 Gene
Abstract
KAI1 is a tumor metastases suppressor gene which is capable of blocking the metastatic process without affecting the primary tumorigenesis. Based on our preliminary data, we hypothesize that the KAI1 protein on tumor cells interacts with gp-Fy on the endothelial cells, which activates a signal pathway of the KAI1 molecule, and that this activation eventually leads to cell growth arrest of tumor cells. To test this hypothesis, we will examine whether the interaction of KAI1 and gp-Fy leads to suppression of tumor metastasis in vivo (Task 1), and identify specific peptide sequences that activate KAI1 and to assess the efficacy of the peptides on tumor growth in an animal model (Task 2). We have successfully completed Task 1 and published the results during this cycle. Task 2 is currently underway and one year non-cost extension was requested. Our long-term goal is to elucidate the molecular mechanism of tumor suppression by the KAI1 gene and to develop an effective therapeutic method which restores the function of the KAI1 gene in the metastatic tumor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA467606
Entities
People
- Kounosuke Watabe
Organizations
- Southern Illinois University