fRMSDPred: Predicting Local RMSD Between Structural Fragments Using Sequence Information
Abstract
The effectiveness of comparative modeling approaches for protein structure prediction can be substantially improved by incorporating predicted structural information in the initial sequence-structure alignment. Motivated by the approaches used to align protein structures, this paper focuses on developing machine learning approaches for estimating the RMSD value of a pair of protein fragments. These estimated fragment-level RMSD values can be used to construct the alignment, assess the quality of an alignment, and identify high-quality alignment segments. We present algorithms to solve this fragment-level RMSD prediction problem using a supervised learning framework based on support vector regression and classification that incorporates protein profiles, predicted secondary structure, effective information encoding schemes, and novel second-order pairwise exponential kernel functions. Our comprehensive empirical study shows superior results compared to the profile-to-profile scoring schemes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 04, 2007
- Accession Number
- ADA467651
Entities
People
- George Karypis
- Huzefa Rangwala
Organizations
- University of Minnesota