Antioxidant Prophylaxis in the Prevention of Prostatic Epithelial Neoplasia
Abstract
The Pl's laboratory has relocated to the University of Texas Health Science Center San Antonio TX. This is a report of the work that was conducted at AMC Cancer Research Center Denver CO between March 1 and June 30, 2005. We have submitted a report describing the work performed in Yl of the project in Feb 2005. This 4 month (February 26th 2005 to June 30th 2005) report describes the research accomplishments primarily associated with the Task I as outlined in the approved statement of work. As mentioned in the Yl report we terminated the experiment involving feeding antioxidant supplemented diet in May 2005 (as described in our Yl report). At the termination of the study (16 weeks) serum, prostate and other organs were collected from all the animals. The efficacy of the combination of antioxidants was assessed by histological evaluation of the prostate and modulation of antioxidant enzymes. Data indicate that 90% of the animals in the control group developed high grade PIN while only 10% of the animals in the experimental group developed high grade PIN. In contrast 90% of the animals on the experimental diet developed low grade PIN. This suggests that a combination of antioxidants can reduce or delay the appearance of high grade PIN in Noble rats. Detailed studies to understand the mechanism of action of these antioxidants as proposed are currently in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA467933
Entities
People
- A. P. Kumar
- Lori Gardner
- Nicole Arevalo
- Rita Ghosh
Organizations
- University of Texas Health Science Center at San Antonio