Midkine Promoter-Driven Adenovirus as Potential Therapy for NF1

Abstract

We proposed to test the possibility of using midkine promoter driven adenovirus (AdMk) to selectively kill neurofibroma cells. It is suggested from the literature that midkine is expressed at higher levels in cells and sera of NF1 patients. We initially obtained a version of the AdMk and tested its cytopathic effect on a neurofibroma cell line ST88. However a more recent publication indicated that this virus would be too toxic for normal cells as well. We then obtained from our new collaborator several different modified adenovirus and tested their cytopathic effects. Promoter activities of the midkine and Cox2 are also assayed in several cell lines.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA467964

Entities

People

  • Vivanne Ding

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Biomedical Research
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Epithelial Cells
  • Genetic Disorders
  • Growth Factors
  • Infection
  • Neoplasms
  • Nervous System
  • Nervous System Diseases
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Toxicity
  • Viruses
  • Wound Infections

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).
  • Virology (or Medical Virology).