IMPACT (Imaging and Molecular Markers for Patients with Lung Cancer: Approaches with Molecular Targets and Complementary, Innovative and Therapeutic Modalities)
Abstract
The projects in this proposal specifically target several signal transduction pathways known to be critical for NSCLC pathogenesis including the EGFR pathway and the more downstream ras/raf/Mek/ERK pathway. These projects combine targeted approaches using molecular and imaging techniques to validate activity against a target and monitor response using imaging modalities specific to the receptor using either small molecules or targeted peptide approaches. The Developmental Research projects explore new areas including 1 ) the issue of high morbidity malignant pleural effusion thereby bringing the pulmonologists into the treatment of advanced disease with molecular therapies; and 2) prevention of lung cancer in youth through a highly interactive, entertaining CD-ROM program.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA468009
Entities
People
- Roy Herbst
- Waunki Hong
Organizations
- The University of Texas MD Anderson Cancer Center