MR Imaging Based Treatment Planning for Radiotherapy of Prostate Cancer
Abstract
This work is aimed at MRI-based treatment planning for radiation therapy. The tasks for the third year include (a) develop practical procedures for clinical implementation of MRI simulation; (b) develop guidelines for MRI-based treatment planning dose calculation, and (c) develop quality assurance programs for MRI simulation for prostate cancer treatment. We have developed a technique to create MR-based digitally reconstructed radiographs (DRR) for patient initial setup for clinical applications of MR-based treatment planning for prostate IMRT. The CT and MR images of twenty prostate patients were used for the study. The pelvic bony structures that are relevant for routine clinical patient setup were manually contoured on MRI. The contoured bony structures were assigned a bulk density of 2.0 g/cm3. The MRI based DRRs were generated. The accuracy of the MR based DDRs was quantitatively evaluated by comparing MR-based DRRs with CT-based DRRs for these patients. Our results showed that MR-based DRRs utilizing the outlines of relevant bony structures have an accuracy of about 3 mm, which is adequate for initial patient setup. This technique has been used, in combination with the BAT/in-room CT daily target localization techniques, for the clinical implementation of MRI-based treatment planning for prostate IMRT at FCCC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA468037
Entities
People
- Lili Chen
Organizations
- Fox Chase Cancer Center