The Use of a Cognitive Protectant to Help Maintain Quality of Life and Cognition in Premenopausal Women with Breast Cancer Undergoing Adjuvant Chemotherapy
Abstract
Significant reductions in quality of life and cognitive function are experienced by women with breast cancer receiving adjuvant chemotherapy. These decrements can be identified in some women even several years following treatment. The majority of relevant research has been based on retrospective data in women with breast cancer. Moreover, current estimates suggest that 25% of breast cancers will be diagnosed in women under age 50, and very little data are available regarding younger women's cognitive function and quality of life during chemotherapy. The goal of the proposed study is to examine change in cognitive function and quality of life in 30 pre-menopausal women with breast cancer receiving chemotherapy. To determine if accelerated menopause is associated with change in cognition and quality of life, serum hormone levels, measures of cognitive function, quality of life variables, and symptoms of depression will be assessed. Measures will be collected at baseline before the initiation of chemotherapy, prior to the third cycle of chemotherapy, and following completion of chemotherapy, but prior to any additional treatment. A better understanding of the association between chemotherapy and quality of life is essential to provide appropriate preventive approaches and interventions aimed at maximizing the quality of life and health of young women diagnosed with breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2006
- Accession Number
- ADA468521
Entities
People
- Jennifer R. Klemp
Organizations
- University of Kansas Medical Center