Bisphosphonate-Based Contrast Agents for Radiological Imaging of Microcalcifications

Abstract

An optical imaging system was developed to allow the visualization of novel NIR-tagged radiological contrast agents. A fluorophore-tagged ligand based on alendronate sodium was developed and tested in mice. The system showed strong affinity for physiological calcium and could be further developed as a radiological contrast agent for x-ray mammography.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA468525

Entities

People

  • Matthew R. Palmer

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Arachnoid
  • Biomedical Research
  • Bone Diseases
  • Cancer
  • Contrast
  • Emission Spectra
  • Filters
  • Fluorescence
  • Fluorophores
  • Health Services
  • High Resolution
  • Imaging Techniques
  • Mammography
  • Medical Personnel
  • Neoplasms
  • X Rays

Fields of Study

  • Chemistry
  • Medicine
  • Physics

Readers

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