Non-Invasive Markers of Tumor Growth, Metastases, and Sensitivity to Anti-Neoplastic Therapy
Abstract
The goals of this application are to develop methods to non-invasively differentiate fast and slow growing prostate tumors and also develop methods to evaluate response to anti-angiogenic agents. Validation of the results will be based on tumor growth metastases and microvessel density measurement (anti-angiogenic studies). To date we have focused on optimizing the pulse sequences necessary for lactate detection synthesizing a macromolecular contrast agent and optimizing its use. These goals have been more difficult to achieve but we are now able to localize lactate within a voxel of the tumor with quantitation and have finished synthesizing the macromolecular contrast agent and been using it in studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2007
- Accession Number
- ADA468529
Entities
People
- Jason A Koutcher
Organizations
- Memorial Sloan Kettering Cancer Center