The Significance of Focal Basal Cell Layer Disruption-Induced Immuno-Cell Infiltration in Prostate Cancer Invasion

Abstract

Using multidisciplinary approaches, our studies assessed the physical status of prostate basal cell layers and the impact of basal cells on the biological presentation of associated epithelial cells. Our studies showed that focally disrupted basal cell layers had the following unique features (1) significantly lower proliferation; (2) significantly lower p63 expression; (3) significantly higher apostosis; (4) significantly higher leukocyte infiltration and stromal reactions.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA468534

Entities

People

  • Yang-gao Man

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Epithelial Cells
  • Epithelium
  • Frequency
  • Gene Expression
  • Growth Factors
  • Membranes
  • Neoplasms
  • Programmed Cell Death
  • Prostate
  • Prostate Cancer
  • Stromal Cells

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).