Antagonism of Taxol Cytotoxicity by Prolactin: Implications for Patient Resistance to Chemotherapy

Abstract

The objective of this investigation is to examine the protective effects of prolactin (PRL) against anti-cancer drugs. Three specific aims were formulated: 1) To characterize the protective effects of PRL against several anticancer drugs 2) To determine anti-apoptotic mechanism(s) and 3) To examine the protective effects of PRL in vivo. Good progress has been made in all objectives as follows. First we have shown the protective effects of PRL against taxol cisplatin and vinblastine in more than one breast cancer cell line. Two we defined the window of time for the action of PRL. Three we have established qualitative and quantitative assays for apoptosis. Due to taxol cytotoxicity initial in vivo studies were unsuccessful. Future research will be redirected to an emphasis on anti-cancer drugs other than taxol and the use of SCID rather than PRL4- mice.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA468538

Entities

People

  • Nira Ben-jonathan

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Membrane Structures
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemotherapeutic Agents
  • Chemotherapy
  • Neoplasms
  • Programmed Cell Death
  • Prostate Cancer
  • Proteins
  • Resistance
  • Survival

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).
  • Systems Analysis and Design