Restoration of Wild-Type Activity to Mutant p53 in Prostate Cancer: A Novel Therapeutic Approach
Abstract
A summary is presented of research performed during the second year of a project to explore approaches to restore wild-type function on mutant p53 proteins found in human prostate tumors. p53 mutant proteins derived from prostate tumors are being characterized to determine their suitability. Three specific aims are being pursued. The first is characterizing the interaction of p53 with two distinct classes of its response elements. The second aim is determining the role of mutant p53 proteins in prostate cancer cell proliferation. The final aim is to explore approaches to restore wild-type function to mutant p53 proteins found in prostate cancer. This is a chemical biological approach with the goal of restoring wild-type function to prostate tumor- derived mutant p53 proteins. This research is geared towards preclinical development of a highly targeted therapy for human prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2007
- Accession Number
- ADA468564
Entities
People
- James J. Manfredi
Organizations
- Icahn School of Medicine at Mount Sinai