FGFR4 Downregulation of Cell Adhesion in Prostate Cancer

Abstract

We have made excellent progress in the preliminary stages of our project to examine the role of FGFR4 G388R in altering cell adhesion in prostate cancer. This includes acquiring expertise in the passage and transfection for gene expression studies using prostate cancer cell lines. A key accomplishment is the demonstration of feasibility of ponasterone; A inducibility of FGFR4 expression in PC3 cells. We hope to successfully create these inducible cells to use in our studies of FGFR4 G388R and its role in prostate cancer progression.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA468675

Entities

People

  • April N. Meyer
  • Daniel J. Donoghue
  • Kristine A. Drafahl

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Demonstrations
  • Department Of Defense
  • Gene Expression
  • Information Operations
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Transfection

Fields of Study

  • Biology

Readers

  • Materials Science.
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.