Human-Derived, Plant-Produced Monoclonal Antibody for the Treatment of Anthrax

Abstract

The unpredictable nature of bio-terrorism compels us to develop medical countermeasures that will enable authorities to treat individuals exposed to agents such as anthrax. We report the feasibility of producing a protective, human-derived, monoclonal antibody directed against the protective antigen (PA) of Bacillus anthracis in plants. This was achieved by transient expression using agroinfiltration of Nicotiana benthamiana plants. The resulting antibody was able to neutralize toxin activity in vitro and in vivo at a comparable level to that seen for its hybridoma-produced counterpart.

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Document Details

Document Type
Technical Report
Publication Date
Jan 13, 2005
Accession Number
ADA468690

Entities

People

  • Anna K. Hull
  • Bart Legutki
  • Carolyn J. Criscuolo
  • Gail Chapman
  • Hans Westra
  • Herman Groen
  • Les Baillie
  • Vadim Mett
  • Vidadi Yusibov
  • Wilma Steeman

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Biomedical Research
  • Biotechnology
  • Blood
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chromatography
  • Column Chromatography
  • Corporations
  • Diseases And Disorders
  • Macrophages
  • Medical Countermeasures
  • Molecules
  • Rodents
  • Vaccines

Readers

  • Microbial Pathology
  • Strategic Security Studies