Control of DNA Dehybridization via Nanoparticle Antennas for Antisense Gene Therapy

Abstract

The goal of this proposal is to develop the use of a nanoscale interface to protein translation machinery to control translation. External magnetic fields excite the nanoscale interface and thus switch on translation of a protein. This technique would enable time-specific control of protein expression, and would enable new techniques in disease diagnosis and therapy. These objectives are in line with the original proposal.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA468814

Entities

People

  • Kimberly Hamad-schifferli

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Antisense Elements (Genetics)
  • Chemistry
  • Field Conditions
  • Gene Therapy
  • High Temperature
  • Laser Pulses
  • Magnetic Fields
  • Molecules
  • Nanoparticles
  • Particles
  • Polyethylene Glycols
  • Sequences
  • Surface Chemistry
  • Surface Finishing
  • Therapy
  • Translations

Readers

  • Medical Imaging.
  • Molecular Genetics
  • Quantum Dot Semiconductor Device Photonics and Graphene Optoelectronic Materials and THz Physics.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech