A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Abstract

Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed post transcriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3 untranslated region motif is implicated in this process.

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Document Details

Document Type
Technical Report
Publication Date
Jan 07, 2005
Accession Number
ADA468967

Entities

People

  • Arnab Pain
  • Christoph S. Janssen
  • Georges K. Christophides
  • J. D. Raine
  • Jane M. Carlton
  • Laurence Florens
  • Marianna Karras
  • Matthew Berriman
  • Neil Hall
  • Taco W. Kooij

Organizations

  • Wellcome Sanger Institute

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computer Programming
  • Cycles
  • Gene Expression
  • Genetic Code
  • Life Cycles
  • Malaria
  • Materials
  • Materials Science
  • Molecular Biology
  • Phase Transformations
  • Proteins
  • Spores

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology