Seroincidence and Phylogeny of Human Immunodeficiency Virus Infections in a Cohort of Commercial Sex Workers in Montevideo, Uruguay
Abstract
A cohort study involving 60 human immunodeficiency virus (HIV) negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999 2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participants seroconverted for an incidence-density rate of 6.03 (95% confidence interval 2.21 13.12) per 100 person-years. Inconsistent condom use during client sex (adjusted hazard ratio [AHR] 6.7), during oral sex (AHR 5.6), and at the last sexual encounter (AHR 7.8), and use of marihuana (AHR 5.4) were marginally associated with HIV seroconversion. Five samples were genotyped in the protease and reverse transcriptase regions; three were subtypes B and two were BF recombinants. Full genome analysis of four samples confirmed all three subtype B samples and one of the two BF recombinants. Male transvestite CSWs sustained a high rate of HIV infection. Larger prospective studies are required to better define subtypes and associated sexual and drug-related risk factors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA468969
Entities
People
- Dora Ruchansky
- Gladys Carrion
- James G. Olson
- Jean K. Carr
- Jose C. Russ
- Jose Vinoles
- Lindsay M. Eyzaguirre
- Margarita Serra
- Sergio Sosa-estani
- Silvia M. Montano
Organizations
- Ministry of Health