Short- and Long-Term Immune Responses of CD-1 Outbred Mice to the Scrub Typhus DNA Vaccine Candidate: p47Kp

Abstract

Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA469102

Entities

People

  • Allen L Richards
  • Chien-Chung Chao
  • Guang Xu
  • Ju Jiang
  • Schismita Chattopadhyay
  • Teik-chye Chan
  • Wei-mei Ching

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biomedical Research
  • Cells
  • Data Science
  • Diseases And Disorders
  • Immune System
  • Immunization
  • Information Science
  • Laboratory Animals
  • Lymphatic System
  • Maryland
  • Navy
  • Proteins
  • Rickettsial Diseases
  • Scrub Typhus
  • Vaccines

Fields of Study

  • Biology

Readers

  • Infectious Disease/Epidemiology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology