Semi-Synthesis and In-vitro Anticancer Evaluation of Derivatives of a New Microtubule Poison with a Taxol-Like Mechanism
Abstract
Taccalonolides are plant-derived steroids which act as microtubule poisons on mammalian cells with a taxol-like mechanism. This makes them potentially useful lead compounds for thedevelopment of anti-cancer agents specifically breast cancer. Natural taccalonolide A was modified through selective chemical reactions at various sites in the molecule in preparation for biological tests that will compare the biological effects and potency of the derivatives with that of the starting material. These studies will allow theidentification of those parts of the structure of taccalonolide A that are important for itsbiological activity. Work towards this goal is subject of this report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA469112
Entities
People
- Thomas K. Hemscheidt
Organizations
- University of Hawaiʻi System