BRCA1 in Gene-Specific Coordination of Transcription and DNA Damage Response

Abstract

During the first year of current funding period, we have focused our study on the identification of BRCA1 regulated genes in human breast cancer cells. By combining the genome-wide microarray study and gene-specific approaches, we have discovered a group of genes that were significantly repressed or stimulated by BRCA1, and several genes in this group, such as TIMP-1, S100P, and GABBR1 have been implicated in the development of breast cancer. We have also found that transcriptional regulation by BRCA1 required gene-specific involvement of its cofactor, COBRA1. These findings will serve as the basis for us to explore the role of BRCA1 in transcriptional regulation in the presence of DNA damage. It also provides targets for investigating the dynamic association of BRCA1, the transcriptional machinery, and DNA damage checkpoint protein complex with chromatin templates under the stress conditions.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA469165

Entities

People

  • Jianlong Sun
  • Rong Li

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chromosome Structures
  • Correlation Analysis
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Identification
  • Microarray Analysis
  • Neoplasms
  • Pcr Testing
  • Proteins
  • Regulations

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.