Molecular Genetic and Gene Therapy Studies of the Musculoskeletal System
Abstract
The proposed research projects focuses on bone health, including relevance to the musculoskeletal system in battlefield performance and in battlefield injury. We have utilized state-of-the-art molecular genetic and gene therapy technologies to address fundamental questions in bone biology with particularly emphasis on attempting to clarify gene function for those genes that are involved in digit tip regeneration, bone size, skeletal repair and anabolic response to mechanical loading. The molecular genetic approaches have utilized various knockout mouse models and whole genome microarray analysis for evaluation of gene functions. The gene therapy approaches have utilized various viral and non-viral vectors to transfer gene of interest to treat localized and systemic skeletal deficits. We have successfully accomplished nearly all of the objectives proposed for the past year. The four core facilities funded by this project have contributed enormously to the success of our research activities. Our research activities during the past year have lead to 5 publications and 2 abstracts. We believe that our successful completion of proposed studies will provide a foundation of knowledge 1) that will allow the identification of genes that are involved in regulating skeletal repair, regeneration, and/or as well anabolic response to mechanical stress and 2) that will provide proof of principles in animal models for successful gene therapy applications to accelerate endosteal bone formation and healing of skeletal injuries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA469196
Entities
People
- Subburaman Mohan