Oral Administration of N-Acetyl-D-Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses

Abstract

This is an annual report of the 4th grant year. PI and 2 Research Associates moved to the current Institute in 2003 from East Carolina University. The project was re-started in December 2004 with approval of no-cost extension until 5/23/2008. In this grant period, we found that administration of chitin particles resulted in less likely inhibit the production of IL-10. Although chitin particles induce peritoneal macrophages catalytically active COX-2 in vitro, intraperitoneal administration induces peritoneal macrophages catalytically inactive COX-2. COX-2, cyclooxygenase, is necessary enhancing prostaglandin E2 (PGE2) release. Both IL-10 and PGE2 enhance allergic responses. We have also planned to establish a method producing chitin particles at 500 1,000 gram per batch.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA469207

Entities

People

  • Yoshimi Shibata

Organizations

  • Florida Atlantic University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Carbohydrates
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Chitin
  • Confocal Microscopy
  • Epithelial Cells
  • Fungi
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Polymeric Films
  • Polysaccharides
  • Proteomics

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.
  • Oncology (Cancer Research).