Laminin-5 gamma2 Chain in Breast Cancer Metastasis
Abstract
To metastasize, cancer cells have to break through basement membrane (BM). Laminin-5 is one of the most abundant BM proteins. It consists of three chains alpha3, beta3 and gamma2. DIII domain, a functional EGFR ligand will be released from Ln-5 2 chain by MMPs processing. It has been suggested by our lab that DIII domain may facilitate cancer progression by preventing anoikis. There are paradoxical data in regard of the role of Ln-5 in cancer progression. For example, both the increased and decreased expression levels of Ln-5 subchains are reported in the literature. The fact that gamma2 chain exists in two different forms (as a secreted monomer, or as a part of the Ln-5 heterotrimer) leads us to hypothesize that those two forms may play different roles in cancer progression. In this proposal we will determine if the expression of Ln-5gamma2 monomer is positively correlated with breast cancer cell line tumorigenecity. In addition, we will determine the role of Ln-5gamma2 chain in cancer progression when it is in the context of Ln-5 heterotrimer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA469249
Entities
People
- Shanshan Liu
Organizations
- Vanderbilt University Medical Center