MT 2A Phosphorylation by PKC Mu/PKD Influences Chemosensitivity to Cisplatin in Prostate Cancer

Abstract

The metallothioneins (MT) are a family of small molecular weight trace metal and free radical scavenging proteins well established to play a role in resistance to chemotherapy and radiation in human cancer. MT gene expression is up regulated in response to the presence of heavy metal ions such as zinc. We have previously established a physiological in vitro cell line model of MT induction using Zn, which is significantly associated with resistance to cisplatin chemotherapy in PC. In this report, our data demonstrates that treatment with TPEN, a Zn specific chelator, significantly improves sensitivity to cisplatin in prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA469252

Entities

People

  • Anton Galich
  • Balaji C> Kethandapatti
  • Cheng Du
  • David J Smith
  • Lynette M. Smith
  • Meena Jaagi
  • Wenguang Zhang

Organizations

  • University of Nebraska Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Line
  • Cells
  • Chemical Compounds
  • Chemotherapy
  • Department Of Defense
  • Free Radicals
  • Information Operations
  • Kinases
  • Molecular Weight
  • Neoplasms
  • New Mexico
  • Phosphorylation
  • Prostate
  • Prostate Cancer
  • Resistance
  • Sensitivity

Fields of Study

  • Biology

Readers

  • Materials Science and Engineering.
  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).