Biohazard Detoxification Method Utilizing Magnetic Particles
Abstract
We are developing a novel, integrated system based on superparamagnetic, biocompatible nanospheres for selective and rapid detoxification of biological, chemical, or radioactive toxins from humans. After intravascular injection, the circulating nanospheres would bind to blood-borne toxins due to selective receptors attached to the nanosphere surface. After circulation, a suitable artery or vein is accessed with a small, hand held magnetic filter unit. The blood is purified of the toxin-loaded nanospheres within the unit and the clean blood is returned to the body. The concentrated toxins can now be disposed or submitted for assay or forensics. At the end of the funding period we have accomplished several key technological goals. A) We have a reproducible procedure for producing PEGylated PLGA/PLA nanospheres of discrete size in a range of 100 nm to 500 nm. We have finalized and are in the process of publishing our in vitro work which identifies the biocompatibility and non-toxicity of the designer spheres. B) Further, we have developed a prototype magnetic separator suitable for ambulatory usage and tested its performance in vitro flow models.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2007
- Accession Number
- ADA469264
Entities
People
- Axel J. Rosengart
Organizations
- University of Chicago Medical Center