Understanding the Mechanism through which Matrix Metalloproteinases (MMPs) Contribute to Breast Cancer-Associated Osteolytic Lesions
Abstract
Bone metastasis is a common event during breast cancer progression. Matrix metalloproteinases (MMPs) are often overexpressed in breast cancer and play an important role in tumor progression. Metastatic breast cancer is typically osteolytic and we hypothesize that specific stromal and tumor MMPs contribute to the growth and the development of osteolytic lesions. To address the role of individual stromal MMPs in vivo we used an intratibial model that recapitulates breast tumor induced osteolysis. We demonstrated that stromal MMP-2 is required for mammary tumor growth in bone by contributing to the proliferation and the survival of the tumor. Developing our understanding of the roles of specific MMPs in breast induced-bone osteolysis will hopefully open the way for new therapeutics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA469268
Entities
People
- Sophie Thiolly
Organizations
- Vanderbilt University Medical Center