Development and Implementation of an Objective, Non-invasive, Behaviorally Relevant Metric for Laser Eye Injury
Abstract
The use of lasers by both the military and civilian community is rapidly expanding. Thus, the potential for laser eye injury and retinal damage is increasing. Sensitive and accurate methods to evaluate and follow laser retinal damage are needed. The multifocal electroretinogram (mfERG) has the potential to meet these criteria. In this study, the mfERG was used to evaluate changes to retinal function following laser exposure. Landolt C contrast acuity was also measured in the six behaviorally trained Rhesus monkeys. The monkeys then received Nd:YAG laser lesions (1064 nm, 9 ns pulse width) in each eye. One eye received a single foveal lesion of approximately 0.13 mJ total intraocular exposure (TIE) and the other received six parafoveal lesions which varied in TIE from 0.13 to 4 mJ. mfERGs and behavioral data were collected both pre- and post-exposure. mfERGs were recorded using stimuli that contained 103, 241, and 509 hexagons. Landolt C contrast acuity was measured with five sizes of Landolt C (0.16 to 5.60 cycles/degree) of varying contrast presented on a monitor at 80 cm. mfERG response densities were sensitive to the functional retinal changes caused by the laser insult. In general, larger lesions showed greater mfERG abnormality than smaller. Deficits in contrast acuity were found to be more severe in the eyes with foveal injuries. Although the mfERG and contrast acuity access different levels of the visual system, both are sensitive to laser-induced retinal damage and may compliment tests for laser eye injury triage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA469355
Entities
People
- Bruce Stuck
- Cheryl D. Dicarlo
- Gary L. Martinsen
- Harry Zwick
- John D'andrea