An Over View of the Continuation of the Work of the Mustard Consortium for the Use of the Free and Liposome Encapsulated Antioxidants as a Counter Measure to Mustards

Abstract

The Mustards Consortium has utilized both in vivo and in vitro models simultaneously to continue to elucidate mustard gas pathophysiology. In previous work done by the MC it was found that CEES, the mustard analogue, induced oxidative stress and was its primary mechanism of action. Consequently, NAC (N-acetylcystiene) was found to be protective as a prophylaxis and treatment. A combination of a water and fat soluble antioxidant encapsulated in a liposome (STIMAL) was found to have the best ameliorative effect against CEES> We have initiated development of next generation STIMAL, in order to optimize its ameliorative effect. The mechanism of action of the antioxidants is suspected to be primarily by their effect on redox regulated pathways. In an effort to elucidate the mechanism of action of the antioxidants and the pathophysiology of mustards, profiles are being developed for: gene expression and antioxidant levels, as well as biochemical pathways.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA469403

Entities

People

  • Alfred Sciuto
  • Dana Anderson
  • Keith Crawford
  • Milton G. Smith
  • Peter A. Ward
  • Salil Das
  • William Stone

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Analogs
  • Antioxidants
  • Consortiums
  • Demographic Cohorts
  • Gene Expression
  • Mustard Agents
  • Oxidative Stress
  • Pathophysiology
  • Preventive Medicine
  • Synthetic Membranes

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Systems Analysis and Design
  • Virology (or Medical Virology).