A Genetic Screen for Genes Involved in BRCA 1 Tumor Suppressor Function

Abstract

Based on our initial screening, we have identified a number of candidates that are involved in DNA damage repair pathway mediated by BRCA1, which is an important aspect of tumor suppression of the molecular. As none of the candidates have previously been reported to play a role in DNA damage repair pathway we speculate that some novel components, such as RNA or chromatin structure, might be involved. Once verified and fully investigated, the possible target genes will contribute to the understanding of the biology of inherited breast cancer as well as the diagnosis and treatment of breast, ovarian and possibly other cancers.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2007
Accession Number
ADA469482

Entities

People

  • Inder Verma
  • Quan Zhu

Organizations

  • Salk Institute for Biological Studies

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cells
  • Chromosome Structures
  • Department Of Defense
  • Fibroblasts
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Neoplasms
  • Proteins
  • Resistance
  • Suppressors

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology