Cancer Localization in the Prostate with F-18 Fluorocholine Positron Emission Tomography
Abstract
The purpose of this project is to develop and evaluate fluorine-18 (F-18) fluorocholine (FCH) positron emission tomography (PET) as an imaging technique that can be used to delineate malignant tumors in the prostate gland. The proposed technique works by measuring the tissue metabolism of FCH, a substrate that is preferentially metabolized by cancer cells due to malignant over-expression of the choline transporter and choline kinase enzyme. The project scope covers a clinical study to recruit men with prostate cancer who have elected treatment by radical prostatectomy surgery. These men will undergo preoperative PET scanning to measure F-18 FCH uptake in anatomical sextants of the prostate gland. Imaging results will be compared to histopathologic analyses of the prostatectomy specimen to determine the accuracy of F-18 FCH PET for detecting cancerous prostate sextants. Magnetic resonance microscopy (MRM) followed by complete embedding and close step-sectioning of specimens will produce the histopathologic standard of reference for this study. Based on data collected from 15 subjects so far, the diagnostic sensitivity and specificity of FCH PET for identifying malignant prostate sextants is estimated at 85% and 62% respectively. Because recent technological advances in PET and computerized tomography (CT) may improve accuracy further, the project is being revised to capitalize on the new features of two PET/CT scanners to be installed at the contract performing organizations in 2007. This revision is expected to enhance the clinical relevance of the final study results. Project completion will require a one-year no-cost extension. To support this change in project scope, we report: 1) an interim analysis of the data, 2) a study on the feasibility of FCH PET/CT guided prostate radiation therapy, and 3) the application of new PET imaging techniques (list-mode and time-of-flight PET) to prostate imaging.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2007
- Accession Number
- ADA469534
Entities
People
- Gregory Thibault
- Isabel A. Sesterhenn
- Marc N. Coel
- Richard Stack
- Sandi A. Kwee
Organizations
- The Queen's Medical Center