Elucidation of the Molecular Mechanism Underlying Lymph Node Metastasis in Prostate Cancer
Abstract
Metastatic spread of prostate cancer is the second leading cause of deaths of men in theUnited States. Although there are many ways to treat non-metastatic form of prostate cancer ,only androgen-deprivation therapy is available for the extensive stage. Again, the cancerwill often progress to an androgen refractory (independent), metastatic stage. Recent reportshave suggested that the expression of VEGF-C and its receptor VEGFR-3 are directly correlatedwith lymph node dissemination in prostate cancer. This finding leads us to think thatunderstanding the role of angiogenic molecules like VEGF-C, -D in molecular detail forlymphatic formation in prostate cancer will provide us the information regarding theirrelationship with lymph node metastasis. We have observed significant increase in reactiveoxygen species and activation of small GTPase RalA upon androgen withdrawal, which in turnupregulates VEGF-C in prostate cancer cells. Interestingly our results suggest a function ofVEGF-C, which is directly related to its role in increasing the metastatic propensity ofprostate cancer rather than inducing lymphangiogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2006
- Accession Number
- ADA469826
Entities
People
- Kaustubh Datta
Organizations
- Mayo Clinic