New Advanced Technology to Improve Prediction and Prevention of Type 1 Diabetes

Abstract

The hypothesis to be tested is that there are allelic variations of some genes that make the development of diabetesrelated complications more likely in patients who carry them than those who do not. The 3 major complications to be evaluated are diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. This is an observational study in which the investigators will obtain DNA samples from the blood of patients with one or more of these complications and from as many their first-degree relatives as possible for testing in the laboratory of Dr. Massimo Trucco is an internationally known immunologist and respected leader in genetic research in diabetes. He will evaluate these samples by studying candidate genes selected a priori and testing for transmission/disequilibrium a standard for analysis of linkage between a candidate gene and a specific disease.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2005
Accession Number
ADA469956

Entities

People

  • Robert A. Vigersky

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Buildings And Structures
  • Department Of Defense
  • Electronic Mail
  • Genetic Testing
  • Information Operations
  • Institutional Review Board
  • Neuropathy
  • Physical Examination (Medicine)
  • Quality Of Life
  • Research Facilities
  • Retinopathy
  • Standards

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular Genetics

Technology Areas

  • Biotechnology