NSAIDS and the Osteogenic Response to Mechanical Stress in Premenopausal Women
Abstract
This is a study of the effects of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), on the osteogenic response to 9 months of exercise training in healthy, premenopausal women, aged 21 to 40 years (N=102). The hypotheses are: H1a: taking short-acting NSAIDS before exercise will diminish increases in bone mineral density (BMD) in response to exercise training H1b: taking short-acting NSAIDS after exercise will not diminish the increases in BMD in response to exercise training Participants take either ibuprofen (400mg) or placebo capsules before and after each exercise session. Women are randomized to three treatment arms: 1) NSAID before exercise, placebo after exercise (NSAID/placebo; n=34); 2) placebo before exercise, NSAID after exercise (placebo/NSAID; n=34); and 3) placebo before exercise, placebo after exercise (placebo/placebo; n=34). One hundred thirteen women completed baseline testing and were randomized to treatment. Final follow-up testing was completed approximately 7 months ago and most sample analysis has been completed. Re-analysis of some samples and review of the database continues for quality assurance. Manuscript preparation is underway. These studies could lead to the development of new strategies to reduce the incidence of, and treatment for, stress fractures that occur in response to vigorous physical activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA469961
Entities
People
- Robert S. Schwartz
- Wendy Kohrt
Organizations
- University of Colorado Health