Chemoprevention Against Breast Cancer with Genistein and Resveratrol
Abstract
Breast cancer a destructive disease despite new therapeutics. It is well accepted that environmental factors, especially diet, can play an important role in determining one s future risk of the disease. We believe that two natural polyphenols, genistein (a component of soy) and sesveratrol (a component of grapes and red wine), can suppress mammary carcinogenesis. We and others have clearly shown a mammary-protective effect against chemically-induced mammary cancer. This pronect aims to elucidate mechanisms through which these polyphenols may exert their effects. We show that genistein and resveratrol can modulate the protein expression of several critical proteins in the mammary gland that are involved in growth and proliferation. We see changes in both the MAPK signaling pathway, the PI3K/Akt pathway, as well as changes in sex steroid receptor co-activators. We have demonstrated that the estrogen receptors play an important role in the mechanisms of genistein and resveratrol. Lastly, we show that a novel mouse model that over-expresses AIB1 may not be suitable for early exposure, chemoprevention experiments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA469973
Entities
People
- Coral A. Lamartiniere
- Timothy G. Whitsett Jr.
Organizations
- University of Alabama