Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors

Abstract

The overall purpose of this research is to develop a polymeric drug delivery system containing magnetic resonance contrast agents for the treatment of breast cancer. This drug-imaging agent delivery system will allow the follow up of the fate of the drug delivery system and its relation to reduced tumor mass, improved efficacy and reduced toxicity in individual patients. In year two progress was made in the following areas: 1) Synthesis of polymer- contrast agent- doxorubicin conjugates; 2) Physicochemical characterization of polymer- contrast agent- doxorubicin conjugates; and 3) Relaxivity measurements. In addition, a series of polymer- contrast agent conjugates targetable to macrophages were synthesized, characterized, and evaluated in vitro.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2006
Accession Number
ADA469974

Entities

People

  • Bahar Zarabi
  • Hamid Ghandehari

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Autoimmune Diseases
  • Azo Compounds
  • Blood
  • Breast Cancer
  • Cells
  • Diseases And Disorders
  • Drug Therapy
  • Health Services
  • Macrophages
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Mononuclear Phagocyte System
  • Neoplasms
  • Pattern Recognition
  • Recognition
  • Resonance

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Medical Imaging.
  • Prostate Cancer Biology.