A Functional Genomic Analysis of NF1-Associated Learning Disabilities

Abstract

Learning disabilities severely deteriorate the life of many NF1 patients. However, the pathogenic process for NF1-associated learning disabilities has not been fully understood and an effective therapy is not available. This study was proposed to identify genes that are dysregulated in the hippocampus of the Nf1+/- mouse model by DNA microarray analysis. Characterization of these NF1-affected genes will dramatically improve our understanding of the molecular pathogenesis underlying NF1-associated learning deficits. During the third year of the project, we have focused on determining the biological functions of NF1-affected genes. In addition, we also characterized the effect of lovastatin treatment on genomic expression of the NF1 hippocampus.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2007
Accession Number
ADA470110

Entities

People

  • Shao-jun Tang

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Brain
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Dna Microarrays
  • Enzyme Inhibitors
  • Genetics
  • Hippocampus
  • Intellectual Disability
  • Microarray Analysis
  • Nervous System
  • Proteins
  • Statins
  • Synapses
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Manufacturing Engineering.
  • Molecular Genetics