Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer
Abstract
The P582S C->T and A588T G->A polymorphisms in the Hypoxia-inducible factor-1alpha (HIF-1alpha) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP). Methods: We examined the association of these polymorphisms with CaP among 1,072 incident cases and 1,271 controls, and further explored their joint associations with various prediagnostic plasma hormone levels. Results: The A588T polymorphism was too rare to provide meaningful conclusions and the P582S polymorphism was not associated with CaP. We observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels (>= versus <median) were associated with a reduced risk only among men with the wildtype (OR, 95% CI = 0.74, 0.57-0.97; (Pinteraction) = 0.01). Conclusions: We found no association between these HIF-1alpha gene polymorphisms with CaP, but the interaction between the P582S polymorphism and the IGF axis merits further evaluation in mechanistic studies
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA470130
Entities
People
- Glenn Bubley
Organizations
- Beth Israel Deaconess Medical Center