Polychlorinated Biphenyls, Organochlorines & PD Risk: A Case Control Study in Alaska
Abstract
The intent of this research is to conduct a case control study of Parkinson's Disease (PD) among Alaska Natives to determine the association of exposure to polychlorinated biphenyl (PCBs) residues, organochlorine pesticides and methylmercury with PD. The hypothesis is that increased exposure to these compounds will be associated with an increased risk of PD. Exposure will be determine by direct measurement of serum levels, as these compounds are persistent in body tissues. In addition, lifelong exposure will be estimated by structured interview, including a dietary history with specific attention to intake of fish, marine mammals and wild game, known sources of bioconcentration of these environmentally persistent compounds. The project will be conducted in two phases. Phase 1 is a developmental period and is currently ongoing. During this time, the specific aspects of the study design are being established, detailed protocols are being developed, and the necessary approvals for the research are being obtained. Once Phase 1 is complete, Phase 2 will be initiated. During Phase 2 the study will be conducted.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2007
- Accession Number
- ADA470146
Entities
People
- Caroline M. Tanner