Fish Oil Supplementation and Fatty Acid Synthase Expression in the Prostate: A Randomized Controlled Trial
Abstract
We are conducting a double-blind, placebo-controlled, randomized intervention study to evaluate the effects of Fish Oil (FO) supplementation use on markers of lipid metabolism in prostate tissue samples. The primary endpoints of this trial are fatty acid synthase expression, caveolin-1 expression, changes in lipid raft fractions in the plasma membrane and cell proliferation (KI-87 expression) in benign, pre-neoplastic and neoplastic prostate tissue. The secondary endpoints include measuring the expression of SREBP-1, a transcription factor for fatty acid concentration and change in PSA. Subjects are men from the Portland VA Medical Center (PVAMC), the Oregon Health and Science University (OHSU) and Kaiser Permanente Northwest (KPNW)urology clinics who are scheduled for a repeat biopsy. These men will have had an initial negative biopsy yet are still considered at high risk due to continued elevated prostatic specific antigen (PSA>4micrograms/df), are positive for PIN, have suspicious findings by DRE or TRUS, or other clinical finding. Approximately 5 men per month over 24 months will be recruited and randomized to receive three months of either fish oil capsules (treatment 1) or olive oil (placebo) capsules (treatment 2). Potential confounding cariables are assessed through completion of a comprehensive diet history questionnaire and risk factor questionnaire, assessment of pre and post-treatment PSA and surveillance of medication and supplement use. Compliance will be assessed using pill count and evaluation of RBC fatty acid concentrations. While this study population is limited to men at high risk of disease, the results may be more broadly generalizable to any man considered at risk of prostate cancer due to standard clinical indicators such as a PSA>4micrograms/ml.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA470148
Entities
People
- Jackilen Shannon
Organizations
- Oregon Health & Science University