BRCA1 Protein Complexes: Dynamic Changes and Functions Important in Breast Cancer

Abstract

In this final report, I summarize the major accomplishments achieved during my three-year award period. Initial experiments focused on purification of endogenous BRCA1 complexes; however, the most fruitful work has occurred in characterizing the function of such BRCA1 complexes. I describe here distinct mechanisms for transcriptional stimulation and repression. These activities recapitulate the in vivo transcriptional functions of BRCA1.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA470582

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  • Andrew Horwitz

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  • Harvard Medical School

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