The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer
Abstract
The tasks outlined in the Statement of Work for the first year of research on the action of ADAM9 isoforms in tumor-stromal interactions encompassed the creation of reagents to properly and thoroughly study the problem as well as preliminary work studying exogenous ADAM9 in a cell-based system. The major developments during this research period were preliminary data showing that the longer form of ADAM9 (ADAM9-L) enhances the migration of breast cancer cells and that this is dependent on it's metalloprotease activity and the development of an ADAM9-S(secreted form) antibody which allows us to detect both isoforms endogenously allowing for the development of more rigorous models using siRNA and endogenous protein to more thoroughly test our hypothesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA470594
Entities
People
- Jessica L. Fry
Organizations
- Beth Israel Deaconess Medical Center