Role of Polyamine Oxidase (PAOh1/SMO) in Human Breast Cancer

Abstract

This report provides an update on the study of the role of polyamine oxidase(PAOh1/SMO, spermine oxidase) in drug response of human breast cancer. Thecytotoxic effects of two novel polyamine analogue compounds, CGC-11144 and CGC- 11047 were evaluated in the human breast cancer cell lines MDA-MB-231, Hs578t,MCF-7, 468, and T47D. Additionally, the hypothesis that induction of spermine oxidase by pro-inflammatory agents plays a role in carcinogenesis was evaluated using a model system of exposure of MCF-10a human breast epithelial cells tocigarette smoke extract (CSE).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA470618

Entities

People

  • Andrew C. Goodwin
  • Talmesha A. Richards

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Amines
  • Analogs
  • Anatomy
  • Bacterial Infections
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemotherapeutic Agents
  • Department Of Defense
  • Enzymes
  • Epithelial Cells
  • Inhibition
  • Metabolism
  • Neoplasms

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