The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study (Idea Award)
Abstract
To explore the effects of exercise training on tumor vascularity and response to neoadjuvant therapy in operable breast cancer in a phase I-II randomized design. Method: Using a two-armed, prospective, randomized design, potential participants will be identified and screened for eligibility via medical record review of patients scheduled for their primary neoadjuvant chemotherapy treatment consultation at DUMC. Following the successful completion of all baseline assessments participants will be randomly assigned to an exercise or control group. Participants assigned to combined exercise training and chemotherapy will perform an individualized exercise training program consisting of three cycle ergometry sessions per week at approximately 60-80% of VO2peak on nonconsecutive days for the duration of neoadjuvant chemotherapy (approximately 12 weeks). Most Significant Research Finding During Reporting Period: As per our statement of work, human ethnical approval was obtained (Task 1); all exercise testing / training procedures and clinical protocols were clarified (Task 2), and data collection has been initiated (Task 3). To date, all 3 patients in phase I of the study have been enrolled and no doselimiting toxicities have been identified with acceptable exercise adherence (>60%), thus phase II has been initiated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2006
- Accession Number
- ADA470637
Entities
People
- Bercedis Peterson
- Jason D. Allen
- Jay Baker
- Kimberly Blackwell
- Lee W. Jones
- Mark W. Dewhirst
- P. K. Marcom
- William Kraus
Organizations
- The University of Texas MD Anderson Cancer Center