Closed-Loop Resuscitation of Hemorrhagic Shock: Novel Solutions Infused to Hypotensive and Normotensive Endpoints

Abstract

To define optimal fluid resuscitation regimens for use in combat casualty care. Specific goals are to determine the infusion regimens and fluids that are most efficient (least volume) and most effective (lowest mortality with best cardiovascular and metabolic function). We tested both FDA approved fluids and novel formulations. Our long-term goal is to develop efficient and efficacious resuscitation regimens for combat casualty care and to develop a microprocessor controlled closed-loop resuscitation system that will optimize the delivery of the solution(s) found best. Over the 3.75-year grant we completed 16 full studies, a total of 24 treatment groups with 218 individual experiments. Using our multi-bleed model conscious sheep hemorrhage model we studied 18 treatment groups in 124 experiments.

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Document Details

Document Type
Technical Report
Publication Date
Jun 29, 2007
Accession Number
ADA470719

Entities

People

  • George C. Kramer

Organizations

  • University of Texas Medical Branch

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Analgesia
  • Blood
  • Blood Flow
  • Blood Volume
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Combat Casualty Care
  • Drug Therapy
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Medical Personnel
  • Nato
  • Patient Care
  • Resuscitation
  • Therapy

Fields of Study

  • Medicine

Readers

  • Robotics and Automation.
  • Trauma Surgery or Emergency Medicine.