Topical Application of Liposomal Antioxidants for Protection Against CEES Induced Skin Damage
Abstract
The objective of this study is to develop an effective prophylactic therapy against an analog of mustard gas, 2-chloroethylethyl sulfide (CEES). The therapy for CEES-induced skin damage will be based on the topical application of antioxidant liposomes. We will use EpiDerm cultured human skin tissues as well as cultured keratinocytes as working models. HD/CEES-induced pathophysiology involves oxidative stress. Liposomes, containing both water- and lipid-soluble antioxidants, are expected to be an effective antidote/therapeutic product to protect US military and civilians from a chemical warfare agent such as HD. The therapeutic efficacy, as well as the chemical and physical stability of various antioxidant liposome formulations, will be examined to determine the optimal preparation for future testing in animal models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2007
- Accession Number
- ADA470814
Entities
People
- Hongsong Yang
- Victor Paromov
- William L. Stone
Organizations
- East Tennessee State University